abstract：:New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

journal_title：International immunopharmacology

authors： Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

更新日期：2009-11-01 00:00:00

abstract：:Probiotics, defined as live microbial food supplements which improve the health of the host, have obtained increasing medical importance. In the intestine they may prevent the overgrowth of pathogenic bacteria, increase the resistance of the gut to invasion by pathogens and ameliorate disease processes by inducting th...

journal_title：International immunopharmacology

authors： Paolillo R,Romano Carratelli C,Sorrentino S,Mazzola N,Rizzo A

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:It has been demonstrated that serum leptin is elevated in females with allergic rhinitis. Recently, it has been reported that one course of sublingual immunotherapy (SLIT) does not affect serum leptin levels. OBJECTIVE:The aim of this study was to evaluate the serum leptin levels in a cohort of patients wit...

journal_title：International immunopharmacology

authors： Ciprandi G,De Amici M,Tosca M,Negrini S,Murdaca G,Marseglia GL

更新日期：2009-09-01 00:00:00

abstract：:Green tea polyphenols have been reported to have anti-inflammatory activities, although the molecular mechanisms responsible for this effect remain unclear. In the present study, we examined the effect of green tea extract and a variety of polyphenolic compounds on spreading of peripheral blood polymorphonuclear leuko...

journal_title：International immunopharmacology

authors： Kori S,Namiki H,Suzuki K

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is characterized by a Th2 polarized immune response and soluble HLA (sHLA) molecules play an immunomodulatory role in this response. Previously, it has been reported that these molecules are increased in sera of patients with pollen-induced allergic rhinitis studied outside the pollen ...

journal_title：International immunopharmacology

authors： Ciprandi G,Contini P,Murdaca G,DeAmici M,Gallina AM,Puppo F

更新日期：2009-08-01 00:00:00

abstract：:Several sesquiterpene lactones that have been isolated from medicinal plants are known to have many pharmacological activities. In this study, we investigated the anti-inflammatory effects of zedoarondiol, a sesquiterpene lactone isolated from the rhizoma of Curcuma heyneana, in lipopolysaccharide (LPS)-stimulated mac...

journal_title：International immunopharmacology

authors： Cho W,Nam JW,Kang HJ,Windono T,Seo EK,Lee KT

更新日期：2009-08-01 00:00:00

abstract：:Monocytes and macrophages of individuals with allergic diseases express increased levels of the low-affinity IgE receptors (FcepsilonRII or CD23) on their surfaces. The cross-linking of CD23-bound IgE antibody by allergen activates the cells to release inflammatory mediators. In mast cells, the binding of IgE to the h...

journal_title：International immunopharmacology

authors： Ezeamuzie CI,Al-Attiyah R,Shihab PK,Al-Radwan R

更新日期：2009-08-01 00:00:00

abstract：:H1-antihistamines are known to be important modulators of inflammatory response. However, the information about the influence of these drugs on reactive nitrogen species generation is still controversial. The main aim of the present study was to investigate the effects of selected H1-antihistamines on nitric oxide pro...

journal_title：International immunopharmacology

authors： Králová J,Racková L,Pekarová M,Kubala L,Nosál R,Jancinová V,Cíz M,Lojek A

更新日期：2009-07-01 00:00:00

abstract：:Despite scopolin is a main coumarin constituent in the stems of Erycibe obtusifolia Benth, a herb drug that has long been utilized in traditional Chinese medicine for the treatment of rheumatoid arthritis, little information is available about the pharmacological activities of this compound. The present study was perf...

journal_title：International immunopharmacology

authors： Pan R,Dai Y,Gao X,Xia Y

更新日期：2009-07-01 00:00:00

abstract：:In the present study, we investigated that (-)-aptosimon, isolated from flower buds of Daphne genkwa, inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Similarly, (-)-aptosimon suppressed tumor necrosis factor (TNF)-alph...

journal_title：International immunopharmacology

authors： Lee MY,Park BY,Kwon OK,Yuk JE,Oh SR,Kim HS,Lee HK,Ahn KS

更新日期：2009-07-01 00:00:00

abstract：:Cellular and molecular events in vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated. SHR-derived VSMC showed increased proliferative capacity and MAP kinase levels in comparison with WKY-derived VSMC. Flow cytometry analysis revealed that progre...

journal_title：International immunopharmacology

authors： Lee SJ,Kim WJ,Moon SK

更新日期：2009-07-01 00:00:00

abstract：:In our previous study, we reported the isolation of a novel humulene derivative, 5-hydroxyzerumbone, from Zingiber zerumbet and its inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 mouse macrophage cells. This study was performed to examine its mechanism of action on th...

journal_title：International immunopharmacology

authors： Min HY,Kim MS,Jang DS,Park EJ,Seo EK,Lee SK

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:M30-Apoptosense and M65 ELISAs can detect caspase cleaved and intact forms of cytokeratin 18. As biologic marker of cell death, both assays can be useful to evaluate prognosis and chemotherapy response in the patients with breast, lung, and endometrium cancer. In the present study, we measured serum M30 and ...

journal_title：International immunopharmacology

authors： Ozturk B,Coskun U,Sancak B,Yaman E,Buyukberber S,Benekli M

更新日期：2009-05-01 00:00:00

abstract：:Experimental autoimmune encephalomylitis (EAE), an animal mode of multiple sclerosis (MS), was previously considered that be mediated by Th1 cells. However, a number of recent studies provided strong evidence that T helper cells that produce IL-17 play a dominant role in the pathogenesis of EAE. Curcumin (1,7-Bis 94-h...

journal_title：International immunopharmacology

authors： Xie L,Li XK,Funeshima-Fuji N,Kimura H,Matsumoto Y,Isaka Y,Takahara S

更新日期：2009-05-01 00:00:00

abstract：:Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

journal_title：International immunopharmacology

authors： Jani A,Chi T,Wan YY

更新日期：2009-05-01 00:00:00

abstract：:This study investigated apoptotic mechanisms of down-expression vascular endothelial growth factor (VEGF) by short interfering RNA (siRNA) in human breast cancer MCF-7 cells. Human breast cancer cells were evaluated for the expression of VEGF and VEGF receptor 2 (VEGFR-2). siRNA targeting VEGF mRNA were chemically syn...

journal_title：International immunopharmacology

authors： Ge YL,Zhang X,Zhang JY,Hou L,Tian RH

更新日期：2009-04-01 00:00:00

abstract：:Cudratricusxanthone A (CTXA), isolated from the roots of Cudrania tricuspidata Bureau (Moraceae) has an isoprenylated xanthone skeleton that is known to exert a variety of biological activities. In the present study, we demonstrated that CTXA inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase ...

journal_title：International immunopharmacology

authors： Jeong GS,Lee DS,Kim YC

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Abnormal angiogenesis is a central hallmark for the development and progression of idiopathic pulmonary fibrosis. It has been shown that vascular endothelial growth factor (VEGF) is one of the critical angiogenic factors in angiogenesis. The aim of the present study was to assess whether disruption of VEGF pa...

journal_title：International immunopharmacology

authors： Ou XM,Li WC,Liu DS,Li YP,Wen FQ,Feng YL,Zhang SF,Huang XY,Wang T,Wang K,Wang X,Chen L

更新日期：2009-01-01 00:00:00

abstract：:In the present study, possible role of phosphodiesterase 7 (PDE7) in development and function of cytotoxic T lymphocyte (CTL) was examined using ASB16165, a specific inhibitor for PDE7. ASB16165 inhibited generation of CTL activity in mixed lymphocyte reaction (MLR), in which splenocytes from C57BL/6N mice were stimul...

journal_title：International immunopharmacology

authors： Kadoshima-Yamaoka K,Murakawa M,Goto M,Tanaka Y,Inoue H,Murafuji H,Hayashi Y,Nagahira K,Miura K,Nakatsuka T,Chamoto K,Fukuda Y,Nishimura T

更新日期：2009-01-01 00:00:00

abstract：:Due to the broad anti-inflammatory and immunomodulatory actions of phosphodiesterase (PDE) 4 inhibitors, it has been proposed that PDE4 inhibitors might be efficacious for skin disorders such as atopic dermatitis. KF66490 is a newly developed PDE4 inhibitor that inhibits PDE4B (IC(50)=220 nM) and the production of tum...

journal_title：International immunopharmacology

authors： Harada D,Takada C,Nosaka Y,Takashima Y,Kobayashi K,Takaba K,Manabe H

更新日期：2009-01-01 00:00:00

abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

journal_title：International immunopharmacology

authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

更新日期：2008-12-20 00:00:00

abstract：BACKGROUND:Triptolide, the principal active ingredient in the extract of Chinese herb Tripterygium wilfordii Hook , has both anti-inflammatory and immunomodulatory activities. However, the potential therapeutic role of triptolide in IBD was still unknown. Interleukin-10 deficient mice, a well characterized experimental...

journal_title：International immunopharmacology

authors： Wei X,Gong J,Zhu J,Niu L,Zhu W,Li N,Li J

更新日期：2008-12-20 00:00:00

abstract：:NC/Nga mice are atopic prone mice that can be an animal model for human atopic dermatitis (AD). Dendritic cells (DC) as professional antigen-presenting cells (APC) are the most capable inducers of immune responses. The present study using BALB/c, C57BL/6J, and NC/Nga male mice investigated whether differentiation and ...

journal_title：International immunopharmacology

authors： Koike E,Takano H,Inoue K,Yanagisawa R

更新日期：2008-12-20 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP), a high-energy glycolytic pathway intermediate, is reported to have a salutary effect in endotoxic shock and sepsis, but its underlying mechanism of action in inflammation is incompletely understood. In this study, our aim was to examine the function of FDP on acute lung injury (ALI) ind...

journal_title：International immunopharmacology

authors： Yin H,Jin XB,Gong Q,Yang H,Hu LY,Gong FL,Zhu JY

更新日期：2008-12-20 00:00:00

abstract：:Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral ...

journal_title：International immunopharmacology

authors： Cruz EA,Da-Silva SA,Muzitano MF,Silva PM,Costa SS,Rossi-Bergmann B

更新日期：2008-12-10 00:00:00

abstract：:T lymphocytes play central roles in adaptive immunity. Lycium barbarum L. (L. barbarum), also known as wolfberry, is a Chinese herbal medicine with various biological activities, such as enhancing immunity, protecting liver damage, and reducing the side effects of chemotherapy and radiotherapy. Here, we report that po...

journal_title：International immunopharmacology

authors： Chen Z,Kwong Huat Tan B,Chan SH

更新日期：2008-12-10 00:00:00

abstract：:Methylglyoxal is a normal metabolite and has the potential to affect a wide variety of cellular processes. In particular, it can act selectively against malignant cells. The study described herein was to investigate whether methylglyoxal can enhance the non-specific immunity of the host against tumor cells. Methylglyo...

journal_title：International immunopharmacology

authors： Bhattacharyya N,Pal A,Patra S,Haldar AK,Roy S,Ray M

更新日期：2008-11-01 00:00:00

abstract：:The anti-inflammatory effects of glycyrol, a benzofuran coumarin isolated from Glycyrrhizae Radix, were studied. Glycyrol of 5, 25 and 50 microM dose-dependently inhibited nitric oxide (NO) production by down-regulating inducible nitric oxide synthase (iNOS), and alleviated cyclooxygenase-2 (COX-2) expression in LPS-s...

journal_title：International immunopharmacology

authors： Shin EM,Zhou HY,Guo LY,Kim JA,Lee SH,Merfort I,Kang SS,Kim HS,Kim S,Kim YS

更新日期：2008-11-01 00:00:00

abstract：:Immunotherapy is the only effective treatment for scorpion stings. However the efficiency of this treatment varies depending on the forms of the antibodies and route of administration used. The antibodies are mostly injected as F(ab )(2) fragments. In this study, we investigated damage to the heart and lung tissue and...

journal_title：International immunopharmacology

authors： Sami-Merah S,Hammoudi-Triki D,Martin-Eauclaire MF,Laraba-Djebari F

更新日期：2008-10-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system as they can act as initiators, stimulators and regulators of the immune response. Human DCs are most commonly generated for clinical use by in vitro differentiation of monocytes with exogenous cytokines. Here, we investigate the ef...

journal_title：International immunopharmacology

authors： Gillet-Hladky S,Duperrier K,Picandet S,Mathias V,de Carvalho MC,Bernaud J,Masseau D,Bienvenu J,Rigal D

更新日期：2008-09-01 00:00:00

abstract：:Human beta-defensin 2 is an antimicrobial peptide that is produced by several epithelial cells after stimulation with micro-organisms and inflammatory mediators. Gram-negative bacteria, which are typically detected in periodontal pockets in periodontitis, elicit a stronger antibacterial peptide response of human beta-...

journal_title：International immunopharmacology

authors： Rizzo A,Paolillo R,Buommino E,Lanza AG,Guida L,Annunziata M,Carratelli CR

更新日期：2008-09-01 00:00:00

abstract：:Excessive activation of microglial cells has been implicated in various neurodegenerative diseases. Resveratrol, a polyphenolic compound found in grapes and wine, has been reported to reduce the activation of microglia. In the present study, 5-[2-(4-bromothiophen-2-yl)vinyl]benzene-1,3-diol (RV09), a novel resveratrol...

journal_title：International immunopharmacology

authors： Meng XL,Yang JY,Chen GL,Zhang LJ,Wang LH,Li J,Wang JM,Wu CF

更新日期：2008-08-01 00:00:00

abstract：:Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFNalpha differently regulated the expression of granzymes in NK cells. Althoug...

journal_title：International immunopharmacology

authors： Zhang B,Zhang J,Tian Z

更新日期：2008-07-01 00:00:00

abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

journal_title：International immunopharmacology

authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

更新日期：2008-06-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has a multitude of biological activity and is associated with a number of inflammatory and immune diseases, including rheumatoid arthritis (RA). The increased serum levels of MIF in patients not only suggest this protein as a marker for disease progression, but also as a po...

journal_title：International immunopharmacology

authors： Li S,Zhang R,Li P,Yi W,Zhang Z,Chen S,Su S,Zhao L,Hu C

更新日期：2008-06-01 00:00:00

abstract：:The abundantly available source of stem cells and the low incidence of graft-versus-host disease (GVHD) made cord blood an attractive alternative source of hematopoietic stem cells for transplantation. Besides T cell and NK cell, NKT cell played an important role in low incidence of GVHD during allogeneic transplantat...

journal_title：International immunopharmacology

authors： Wang Y,Zheng X,Wei H,Sun R,Tian Z

更新日期：2008-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a vital component of the inflammatory process and its aberrant over-expression has been linked to numerous disease states. New treatment strategies have sought to reduce circulating TNF-alpha, either with neutralizing anti-TNF-alpha binding proteins such as etanercept or via ...

journal_title：International immunopharmacology

authors： Grattendick KJ,Nakashima JM,Feng L,Giri SN,Margolin SB

更新日期：2008-05-01 00:00:00

abstract：:The mast cells have been suggested to be a cellular source of nitric oxide (NO) which level is increased in the pathogenesis of asthma. However, isoforms of the NO generating enzyme, nitric oxide synthase (NOS), in primary human mast cells have not been defined due to the lack of a suitable model. We hence examined di...

journal_title：International immunopharmacology

authors： Yip KH,Huang Y,Waye MM,Lau HY

更新日期：2008-05-01 00:00:00

abstract：:The inner surface of the intestinal tract possesses a large area of mucosal membranes, and the intestinal epithelial cells exist at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria. The crosstalk that occurs between these compartments serves to maintain intestinal homeostasis, and the c...

journal_title：International immunopharmacology

authors： Matsumoto T,Moriya M,Sakurai MH,Kiyohara H,Tabuchi Y,Yamada H

更新日期：2008-04-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00